Abnormal ovarian cycles as diagnosed by ultrasound and serum estradiol levels

M. L. Polan, M. Totora, B. V. Caldwell, A. H. DeCherney, F. P. Haseltine, N. Kase

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A significant portion of human infertility is presumably due to defective ovulation, including patients who fail to conceive despite medical induction of ovulation, those who fail despite repeated timely donor inseminations, and those with 'infertility of unknown etiology'. All point out the inadequacy of standard criteria for normal ovulation. This investigation correlates preovulatory serum estradiol and gonadotropin concentrations with dominant follicle growth measured ultrasonographically and serum progesterone levels. The data indicate a 35% incidence of cycles with significantly abnormal serum estradiol levels, decreased dominant follicle size, and abnormal progesterone levels despite biphasic basal body temperature curves and normal cycle length. If these cycles represent inadequate or abnormal ovulation, they can be distinguished from adequate cycles prior to follicle rupture and may benefit the treatment of human infertility.

Original languageEnglish (US)
Pages (from-to)342-347
Number of pages6
JournalUnknown Journal
Issue number3
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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