Abnormal functional lateralization of the sensorimotor cortex in patients with schizophrenia

Venkata S. Mattay, Joseph H. Callicott, Alessandro Bertolino, Attanagoda K.S. Santha, Kathleen A. Tallent, Terry E. Goldberg, Joseph A. Frank, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


PREVIOUS neuroimaging studies have suggested that patients with schizophrenia fail to recruit appropriate local patterns of cortical responses to cognitive tasks. We investigated whether patients with schizophrenia show a normal focal response to a simple motor task. Seven strongly right-handed patients with schizophrenia and seven strongly right- handed normal subjects performed motor tasks of increasing complexity. Patients were unable to recruit as focal a response even to a simple, automatic sequential finger movement task. They showed greater ipsilateral activation in the primary sensorimotor and lateral premotor regions and had a significantly lower laterality quotient than normal subjects. These phenomena increased with the complexity of the task. These results demonstrate a functional disturbance in the cortical motor circuitry of patients with schizophrenia.

Original languageEnglish (US)
Pages (from-to)2977-2984
Number of pages8
Issue number13
StatePublished - 1997
Externally publishedYes


  • Cortex
  • Functional imaging
  • Lateralization
  • Motor function
  • Schizophrenia
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)


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