Aberrant hydrogen sulfide signaling in Alzheimer's disease

Bindu D. Paul

doi:10.1002/9781119799900.ch18

Aberrant hydrogen sulfide signaling in Alzheimer's disease

Bindu D. Paul

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Once considered solely to be a toxic molecule, it is now known that hydrogen sulfide (H ₂ S) is also produced endogenously and participates in a multitude of physiological processes which include vasorelaxation, angiogenesis, response to stress, mitochondrial bioenergetics, and neuronal functions. H ₂ S mediates most, if not all, of these functions through a post-translational modification termed persulfidation/sulfhydration, which occurs on the -SH groups of reactive cysteine residues, converting them to persulfide or -SSH groups. H ₂ S metabolism and sulfhydration are dysregulated during aging and neurodegeneration. In this chapter, we discuss the role of H ₂ S in the brain, with a focus on Alzheimer's disease, the most common form of dementia worldwide and therapeutic opportunities pertaining to H ₂ S metabolism.

Original language	English (US)
Title of host publication	Hydrogen Sulfide
Subtitle of host publication	Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies
Publisher	wiley
Pages	489-505
Number of pages	17
ISBN (Electronic)	9781119799900
ISBN (Print)	9781119799870
DOIs	https://doi.org/10.1002/9781119799900.ch18
State	Published - Sep 2 2022

Keywords

Aging
Alzheimer's disease
Hydrogen sulfide
Neuropathology
Persulfidation

ASJC Scopus subject areas

General Chemistry
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1002/9781119799900.ch18

Cite this

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KW - Hydrogen sulfide

KW - Neuropathology

KW - Persulfidation

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Aberrant hydrogen sulfide signaling in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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