ABC/2: Estimating intracerebral haemorrhage volume and total brain volume, and predicting outcome in children

Jonathan T. Kleinman, Argye E. Hillis, Lori C. Jordan

Research output: Contribution to journalLetterpeer-review

30 Scopus citations


Aim Few data exist to aid the clinician in prognosis after paediatric intracerebral haemorrhages (ICHs). Recently, ICH volume as a per cent of total brain volume (TBV) was shown to help predict outcomes in children. Thus, we sought to develop a bedside method of TBV estimation using typical hospital imaging software, and to validate the ABC/2 method for children in order to determine ICH volume and aid prognosis. Method The study group comprised 23 children and adolescents with non-traumatic, acute ICH who had undergone head computed tomography and who were available for analysis. The median age of participants, 14 males (61%) and nine females (39%), was 6years (range 0-16y; mean 7.8y; SD 5.3y). Preterm infants born at less than 37weeks' gestation and term infants with pure intraventricular haemorrhages were excluded. Manual segmentation, which is the criterion standard for measurement of ICH volume and TBV, requires specialized software and is time-consuming. We therefore used the well-known 'ABC/2×slice thickness' method to calculate ICH volume and TBV, thus allowing ICH size to be reported as a percentage of TBV regardless of the absolute size of ICH. Results The estimated ICH volume was highly accurate compared with the criterion standard (R2=0.97 and R2=0.93; combined R2=0.96), as was the estimated TBV (R2=0.89 and R2=0.77; combined R2=0.89). The interrater reliability was high for both ICH volume and TBV, with an intraclass correlation coefficient of 0.94 and 0.80 respectively. Therefore, using no specialized software, we accurately measured ICH volume as a percentage of TBV. Interpretation The ABC/2× slice thickness method is a possible bedside tool for the clinician that can aid prognosis after paediatric ICH.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalDevelopmental medicine and child neurology
Issue number3
StatePublished - Mar 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


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