A volumetric cone-beam CT system based on a 41×41 cm2 flat-panel imager

D. A. Jaffray, J. H. Siewerdsen

Research output: Contribution to journalConference articlepeer-review

10 Scopus citations


Cone-beam computed tomography (CBCT) based upon large-area flat-panel imager (FPI) technology is a flexible and adaptable technology that offers large field-of-view (FOV), high spatial resolution, and soft-tissue imaging. The imaging performance of FPI-based cone-beam CT has been evaluated on a computer-controlled bench-top system using an early prototype FPI with a small FOV (20.5×20.5 cm2). These investigations demonstrate the potential of this exciting technology. In this report, imaging performance is evaluated using a production grade large-area FPI (41×41 cm2) for which the manufacturer has achieved a significant reduction in additive noise. This reduction in additive noise results in a substantial improvement in detective quantum efficiency (DQE) at low exposures. The spatial resolution over the increased FOV of the cone-beam CT system is evaluated by imaging a fine steel wire placed at various locations within the volume of reconstruction. The measured modulation transfer function (MTF) of the system demonstrates spatial frequency pass beyond 1 mm-1 (10% modulation) with a slight degradation at points off the source plane. In addition to investigations of imaging performance, progress has also been made in the integration of this technology with a medical linear accelerator for on-line image-guided radiation therapy. Unlike the bench-top system, this implementation must contend with significant geometric non-idealities caused by gravity-induced flex of the x-ray tube and FPI support assemblies. A method of characterizing and correcting these non-idealities has been developed. Images of an anthropomorphic head phantom qualitatively demonstrate the excellent spatial resolution and large FOV achievable with the cone-beam approach in the clinical implementation.

Original languageEnglish (US)
Pages (from-to)800-807
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 2001
Externally publishedYes
EventMedical Imaging 2001: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2001Feb 20 2001


  • Amorphous silicon
  • Cone-beam computed tomography
  • Flat-panel detector
  • Radiation therapy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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