A VLSI neural monitoring system with ultra-wideband telemetry for awake behaving subjects

Elliot Greenwald, Mohsen Mollazadeh, Charles Hu, Wei Tang, Eugenio Culurciello, Nitish Thakor

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Long-term monitoring of neuronal activity in awake behaving subjects can provide fundamental information about brain dynamics for neuroscience and neuroengineering applications. Here, we present a miniature, lightweight, and low-power recording system for monitoring neural activity in awake behaving animals. The system integrates two custom designed very-large-scale integrated chips, a neural interface module fabricated in 0.5 \mum complementary metaloxide semiconductor technology and an ultra-wideband transmitter module fabricated in a 0.5 \mu m silicon-on-sapphire (SOS) technology. The system amplifies, filters, digitizes, and transmits 16 channels of neural data at a rate of 1 Mb/s. The entire system, which includes the VLSI circuits, a digital interface board, a battery, and a custom housing, is small and lightweight (24 g) and, thus, can be chronically mounted on small animals. The system consumes 4.8 mA and records continuously for up to 40 h powered by a 3.7-V, 200-mAh rechargeable lithium-ion battery. Experimental benchtop characterizations as well as in vivo multichannel neural recordings from awake behaving rats are presented here.

Original languageEnglish (US)
Article number5759105
Pages (from-to)112-119
Number of pages8
JournalIEEE Transactions on Biomedical Circuits and Systems
Issue number2
StatePublished - Apr 2011


  • Biopotential amplifier
  • digital telemetry
  • electrocorticogram
  • electroencephalogram
  • headmounted systems
  • local field potentials
  • micropower instrumentation
  • neural interface
  • ultra-wideband telemetry
  • wireless neural recording

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering


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