TY - JOUR
T1 - A vector wiener filter for dual-radionuclide imaging
AU - Links, Jonathan M.
AU - Prince, Jerry L.
AU - Gupta, Sandccp N.
N1 - Funding Information:
Manuscript received April 10, 1995; revised May 31, 1996. This work was supported by the National Institutes of Health under Grant R01-CA32845 and the National Science Foundation under Grant MIP93-50336. The Associate Editor responsible for coordinating the review of this paper and recommending its publication was V. Johnson. Asterisk indicates corresponding author. J. M. Links is with the Department of Environmental Health Sciences and Department of Electrical and Computer Engineering, The Johns Hopkins University School of Public Health, Baltimore, MD 21205 USA. *J. L. Prince is with the Department of Electrical and Computer Engineering, 105 Barton Hall, Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 USA (e-mail: [email protected]). He is also with the Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA. S. N. Gupta is with the Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218 USA. Publisher Item Identifier S 0278-0062(96)07200-X.
PY - 1996
Y1 - 1996
N2 - The routine use of a single radionuclide for patient imaging in nuclear medicine can be complemented by studies employing two tracers to examine two different processes in a single organ, most frequently by simultaneous imaging of both radionuclides in two different energy windows. In addition, simultaneous transmission/emission imaging with dnalradionuclides has been described, with one radionuclide used for the transmission study and a second for the emission study. There is thus currently considerable interest in dual-radionuclide imaging. A major problem with all dual-radionuclide imaging is the crosstalk between the two radionuclides. Such crosstalk frequently occurs, because scattered radiation from the higher energy radionuclide is detected in the lower energy window, and because the lower energy radionuclide may have higher energy emissions which are detected in the higher energy window. We have previously described the use of Fourier-based restoration filtering in single photon emission computed tomography (SPECT) and positron emission tomography (PET) to improve quantitative accuracy by designing a Wiener or other Fourier filter to partially restore the loss of contrast due to scatter and finite spatial resolution effects. We describe here the derivation and initial validation of an extension of such filtering for dualradiunuclide imaging that simultaneously 1) improves contrast in each radionuclide's direct image, 2) reduces image noise, and 3) reduces the crosstalk contribution from the other radionuclide. This filter is based on a vector version of the Wiener filter, which is shown to be superior [in the minimum mean square error (MMSE) sense] to the sequential application of separate crosstalk and restoration filters.
AB - The routine use of a single radionuclide for patient imaging in nuclear medicine can be complemented by studies employing two tracers to examine two different processes in a single organ, most frequently by simultaneous imaging of both radionuclides in two different energy windows. In addition, simultaneous transmission/emission imaging with dnalradionuclides has been described, with one radionuclide used for the transmission study and a second for the emission study. There is thus currently considerable interest in dual-radionuclide imaging. A major problem with all dual-radionuclide imaging is the crosstalk between the two radionuclides. Such crosstalk frequently occurs, because scattered radiation from the higher energy radionuclide is detected in the lower energy window, and because the lower energy radionuclide may have higher energy emissions which are detected in the higher energy window. We have previously described the use of Fourier-based restoration filtering in single photon emission computed tomography (SPECT) and positron emission tomography (PET) to improve quantitative accuracy by designing a Wiener or other Fourier filter to partially restore the loss of contrast due to scatter and finite spatial resolution effects. We describe here the derivation and initial validation of an extension of such filtering for dualradiunuclide imaging that simultaneously 1) improves contrast in each radionuclide's direct image, 2) reduces image noise, and 3) reduces the crosstalk contribution from the other radionuclide. This filter is based on a vector version of the Wiener filter, which is shown to be superior [in the minimum mean square error (MMSE) sense] to the sequential application of separate crosstalk and restoration filters.
UR - https://www.scopus.com/pages/publications/0030270956
UR - https://www.scopus.com/pages/publications/0030270956#tab=citedBy
U2 - 10.1109/42.538947
DO - 10.1109/42.538947
M3 - Article
C2 - 18215951
AN - SCOPUS:0030270956
SN - 0278-0062
VL - 15
SP - 700
EP - 709
JO - IEEE transactions on medical imaging
JF - IEEE transactions on medical imaging
IS - 5
ER -