A Valved Expanded Polytetrafluoroethylene Conduit can Acquire Endothelium After Implantation

Sudesh Prabhu; Srikanth Kasturi; Sruti Rao; Riyan Shetty; Shreesha Maiya; Tom R. Karl

doi:10.1177/21501351231204332

A Valved Expanded Polytetrafluoroethylene Conduit can Acquire Endothelium After Implantation

Sudesh Prabhu, Srikanth Kasturi, Sruti Rao, Riyan Shetty, Shreesha Maiya, Tom R. Karl

Research output: Contribution to journal › Article › peer-review

Abstract

We demonstrate histopathology, neointimal proliferation, and neo-endothelialization in an explanted valved expanded polytetrafluoroethylene (ePTFE) conduit 40 months postimplantation that was void of calcification and inflammation, confirmed by CD-31 positivity on immunohistochemistry. Grossly, there was no distortion with preserved leaflets and lack of calcification. Good biocompatibility, nonreactivity, and low antigenicity, combined with neointimal and endothelial layer generation within the conduit might explain the low infection rates and minimal thrombogenicity. These findings support the use of handmade, valved ePTFE conduits as an economically viable option as a right ventricle to pulmonary artery conduit.

Original language	English (US)
Pages (from-to)	239-242
Number of pages	4
Journal	World Journal for Pediatric and Congenital Heart Surgery
Volume	15
Issue number	2
DOIs	https://doi.org/10.1177/21501351231204332
State	Published - Mar 2024
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Surgery
Pediatrics, Perinatology, and Child Health

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10.1177/21501351231204332

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abstract = "We demonstrate histopathology, neointimal proliferation, and neo-endothelialization in an explanted valved expanded polytetrafluoroethylene (ePTFE) conduit 40 months postimplantation that was void of calcification and inflammation, confirmed by CD-31 positivity on immunohistochemistry. Grossly, there was no distortion with preserved leaflets and lack of calcification. Good biocompatibility, nonreactivity, and low antigenicity, combined with neointimal and endothelial layer generation within the conduit might explain the low infection rates and minimal thrombogenicity. These findings support the use of handmade, valved ePTFE conduits as an economically viable option as a right ventricle to pulmonary artery conduit.",

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AU - Prabhu, Sudesh

AU - Kasturi, Srikanth

AU - Rao, Sruti

AU - Shetty, Riyan

AU - Maiya, Shreesha

AU - Karl, Tom R.

N1 - Publisher Copyright: © The Author(s) 2023.

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AB - We demonstrate histopathology, neointimal proliferation, and neo-endothelialization in an explanted valved expanded polytetrafluoroethylene (ePTFE) conduit 40 months postimplantation that was void of calcification and inflammation, confirmed by CD-31 positivity on immunohistochemistry. Grossly, there was no distortion with preserved leaflets and lack of calcification. Good biocompatibility, nonreactivity, and low antigenicity, combined with neointimal and endothelial layer generation within the conduit might explain the low infection rates and minimal thrombogenicity. These findings support the use of handmade, valved ePTFE conduits as an economically viable option as a right ventricle to pulmonary artery conduit.

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A Valved Expanded Polytetrafluoroethylene Conduit can Acquire Endothelium After Implantation

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