A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Carol W. Greider; Elizabeth H. Blackburn

doi:10.1038/337331a0

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Carol W. Greider, Elizabeth H. Blackburn

Research output: Contribution to journal › Article › peer-review

1226 Scopus citations

Abstract

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

Original language	English (US)
Pages (from-to)	331-337
Number of pages	7
Journal	Nature
Volume	337
Issue number	6205
DOIs	https://doi.org/10.1038/337331a0
State	Published - Jan 1 1989
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/337331a0

Cite this

@article{ac1580ef252d4ed2b73ec8d775dff85b,

title = "A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis",

abstract = "The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.",

author = "Greider, {Carol W.} and Blackburn, {Elizabeth H.}",

year = "1989",

month = jan,

day = "1",

doi = "10.1038/337331a0",

language = "English (US)",

volume = "337",

pages = "331--337",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "6205",

}

TY - JOUR

T1 - A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

AU - Greider, Carol W.

AU - Blackburn, Elizabeth H.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

AB - The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

UR - http://www.scopus.com/inward/record.url?scp=0024978857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024978857&partnerID=8YFLogxK

U2 - 10.1038/337331a0

DO - 10.1038/337331a0

M3 - Article

C2 - 2463488

AN - SCOPUS:0024978857

SN - 0028-0836

VL - 337

SP - 331

EP - 337

JO - Nature

JF - Nature

IS - 6205

ER -

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this