A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Carol W. Greider; Elizabeth H. Blackburn

doi:10.1038/337331a0

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Carol W. Greider, Elizabeth H. Blackburn

Research output: Contribution to journal › Article › peer-review

1226 Scopus citations

Abstract

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

Original language	English (US)
Pages (from-to)	331-337
Number of pages	7
Journal	Nature
Volume	337
Issue number	6205
DOIs	https://doi.org/10.1038/337331a0
State	Published - 1989
Externally published	Yes

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title = "A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis",

abstract = "The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.",

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year = "1989",

doi = "10.1038/337331a0",

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AB - The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

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JO - Nature

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ER -

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Abstract

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