A tandem one-pot, microwave-assisted synthesis of regiochemically differentiated 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones

Ravindra A. De Silva; Soumava Santra; Peter R. Andreana

doi:10.1021/ol801841m

A tandem one-pot, microwave-assisted synthesis of regiochemically differentiated 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones

Ravindra A. De Silva, Soumava Santra, Peter R. Andreana

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

(Chemical Equation Presented) A one-pot, two-step synthesis of the title compounds employs a multicomponent Ugl condensation reaction, microwave irradiation, and Fe(0) as a reductant. Two pathways are accessible; both routes utilize bifunctional, o-nitro-substituted arenes leading to either C2, N4, C5 substitution (A) or C2, N4 substitution (B).

Original language	English (US)
Pages (from-to)	4541-4544
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	20
DOIs	https://doi.org/10.1021/ol801841m
State	Published - Dec 1 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol801841m

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abstract = "(Chemical Equation Presented) A one-pot, two-step synthesis of the title compounds employs a multicomponent Ugl condensation reaction, microwave irradiation, and Fe(0) as a reductant. Two pathways are accessible; both routes utilize bifunctional, o-nitro-substituted arenes leading to either C2, N4, C5 substitution (A) or C2, N4 substitution (B).",

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AU - De Silva, Ravindra A.

AU - Santra, Soumava

AU - Andreana, Peter R.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - (Chemical Equation Presented) A one-pot, two-step synthesis of the title compounds employs a multicomponent Ugl condensation reaction, microwave irradiation, and Fe(0) as a reductant. Two pathways are accessible; both routes utilize bifunctional, o-nitro-substituted arenes leading to either C2, N4, C5 substitution (A) or C2, N4 substitution (B).

AB - (Chemical Equation Presented) A one-pot, two-step synthesis of the title compounds employs a multicomponent Ugl condensation reaction, microwave irradiation, and Fe(0) as a reductant. Two pathways are accessible; both routes utilize bifunctional, o-nitro-substituted arenes leading to either C2, N4, C5 substitution (A) or C2, N4 substitution (B).

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A tandem one-pot, microwave-assisted synthesis of regiochemically differentiated 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones

Abstract

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