TY - CHAP
T1 - A tale of the good and bad
T2 - Cell senescence in bone homeostasis and disease
AU - Liu, Xiaonan
AU - Wan, Mei
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019
Y1 - 2019
N2 - Historically, cellular senescence has been viewed as an irreversible cell-cycle arrest process with distinctive phenotypic alterations that were implicated primarily in aging and tumor suppression. Recent discoveries suggest that cellular senescence represents a series of diverse, dynamic, and heterogeneous cellular states with the senescence-associated secretory phenotype (SASP). Although senescent cells typically contribute to aging and age-related diseases, accumulating evidence has shown that they also have important physiological functions during embryonic development, late pubertal bone growth cessation, and adulthood tissue remodeling. Here, we review the recent research on cellular senescence and SASP, highlighting the key pathways that mediate senescence cell-cycle arrest and initiate SASP. We also summarize recent literature on the role of cellular senescence in maintaining bone homeostasis and mediating age-associated osteoporosis, discussing both the beneficial and adverse roles of cellular senescence in bone during different physiological stages, including bone development, childhood bone growth, adulthood bone remodeling, and bone aging.
AB - Historically, cellular senescence has been viewed as an irreversible cell-cycle arrest process with distinctive phenotypic alterations that were implicated primarily in aging and tumor suppression. Recent discoveries suggest that cellular senescence represents a series of diverse, dynamic, and heterogeneous cellular states with the senescence-associated secretory phenotype (SASP). Although senescent cells typically contribute to aging and age-related diseases, accumulating evidence has shown that they also have important physiological functions during embryonic development, late pubertal bone growth cessation, and adulthood tissue remodeling. Here, we review the recent research on cellular senescence and SASP, highlighting the key pathways that mediate senescence cell-cycle arrest and initiate SASP. We also summarize recent literature on the role of cellular senescence in maintaining bone homeostasis and mediating age-associated osteoporosis, discussing both the beneficial and adverse roles of cellular senescence in bone during different physiological stages, including bone development, childhood bone growth, adulthood bone remodeling, and bone aging.
KW - Age-associated osteoporosis
KW - Bone aging
KW - Bone development
KW - Bone growth
KW - Bone homeostasis
KW - Cellular senescence
KW - Epigenetic regulation
KW - Senescence-associated secretory phenotype
UR - http://www.scopus.com/inward/record.url?scp=85064159312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064159312&partnerID=8YFLogxK
U2 - 10.1016/bs.ircmb.2019.03.005
DO - 10.1016/bs.ircmb.2019.03.005
M3 - Chapter
C2 - 31122396
AN - SCOPUS:85064159312
SN - 9780128177242
T3 - International Review of Cell and Molecular Biology
SP - 97
EP - 128
BT - International Review of Cell and Molecular Biology
A2 - Galluzzi, Lorenzo
PB - Elsevier Inc.
ER -