A tale of the good and bad: Cell senescence in bone homeostasis and disease

Xiaonan Liu, Mei Wan

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Historically, cellular senescence has been viewed as an irreversible cell-cycle arrest process with distinctive phenotypic alterations that were implicated primarily in aging and tumor suppression. Recent discoveries suggest that cellular senescence represents a series of diverse, dynamic, and heterogeneous cellular states with the senescence-associated secretory phenotype (SASP). Although senescent cells typically contribute to aging and age-related diseases, accumulating evidence has shown that they also have important physiological functions during embryonic development, late pubertal bone growth cessation, and adulthood tissue remodeling. Here, we review the recent research on cellular senescence and SASP, highlighting the key pathways that mediate senescence cell-cycle arrest and initiate SASP. We also summarize recent literature on the role of cellular senescence in maintaining bone homeostasis and mediating age-associated osteoporosis, discussing both the beneficial and adverse roles of cellular senescence in bone during different physiological stages, including bone development, childhood bone growth, adulthood bone remodeling, and bone aging.

Original languageEnglish (US)
Title of host publicationInternational Review of Cell and Molecular Biology
EditorsLorenzo Galluzzi
PublisherElsevier Inc.
Pages97-128
Number of pages32
ISBN (Print)9780128177242
DOIs
StatePublished - 2019

Publication series

NameInternational Review of Cell and Molecular Biology
Volume346
ISSN (Print)1937-6448

Keywords

  • Age-associated osteoporosis
  • Bone aging
  • Bone development
  • Bone growth
  • Bone homeostasis
  • Cellular senescence
  • Epigenetic regulation
  • Senescence-associated secretory phenotype

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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