A systematic review of treatments for refractory depression in older people

Claudia Cooper, Cornelius Katona, Kostas Lyketsos, Dan Blazer, Henry Brodaty, Peter Rabins, Carlos Augusto De Mendonça Lima, Gill Livingston

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


Objective: The authors systematically reviewed the management of treatmentrefractory depression in older people (defined as age 55 or older). Method: The authors conducted an electronic database search and reviewed the 14 articles that fit predetermined criteria. Refractory depression was defined as failure to respond to at least one course of treatment for depression during the current illness episode. The authors rated the validity of studies using a standard checklist and calculated the pooled proportion of response to any treatment reported by at least three studies. Results: All the studies that met inclusion criteria investigated pharmacological treatment. Most were open-label studies, and the authors found no double-blind randomized placebo-controlled trials. The overall response rate for all active treatments investigated was 52% (95% CI=42-62; N=381). Only lithium augmentation was assessed in more than two trials, and the response rate was 42% (95% CI=21-65; N=57). Only two studies included comparison groups receiving no additional treatment, and none of the participants in these groups responded. In single randomized studies, extended-release venlafaxine was more efficacious than paroxetine, lithium augmentation more than phenelzine, and selegiline more than placebo. Conclusions: Half of the participants responded to pharmacological treatments, indicating the importance of managing treatment-refractory depression actively in older people. The only treatment for which there was replicated evidence was lithium augmentation. Double-blind randomized controlled trials for management of treatment-refractory depression in older people, encompassing pharmacological and nonpharmacological therapies and populations that reflect the levels of physical and cognitive impairment present in the general older population with depression, are needed.

Original languageEnglish (US)
Pages (from-to)681-688
Number of pages8
JournalAmerican Journal of Psychiatry
Issue number7
StatePublished - Jul 2011
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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