TY - JOUR
T1 - A systematic review of antibody mediated immunity to coronaviruses
T2 - kinetics, correlates of protection, and association with severity
AU - Huang, Angkana T.
AU - Garcia-Carreras, Bernardo
AU - Hitchings, Matt D.T.
AU - Yang, Bingyi
AU - Katzelnick, Leah C.
AU - Rattigan, Susan M.
AU - Borgert, Brooke A.
AU - Moreno, Carlos A.
AU - Solomon, Benjamin D.
AU - Trimmer-Smith, Luke
AU - Etienne, Veronique
AU - Rodriguez-Barraquer, Isabel
AU - Lessler, Justin
AU - Salje, Henrik
AU - Burke, Donald S.
AU - Wesolowski, Amy
AU - Cummings, Derek A.T.
N1 - Funding Information:
A.P.W. is funded by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund and by the National Library of Medicine of the National Institutes of Health under award number DP2LM013102. D.A.T.C. and A.P.W. were also supported by a grant from the Burroughs Wellcome Fund (1021212). I.R.B. was supported by the John A Watson Faculty Scholar fellowship. We thank Celeste Dale and Maxwell Hogshead for assistance in data digitization.
Funding Information:
This research was supported [in part] by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health. D.A.T.C. was supported by the US National Institutes of Health award number R01-AI114703-01.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.
AB - Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.
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U2 - 10.1038/s41467-020-18450-4
DO - 10.1038/s41467-020-18450-4
M3 - Article
C2 - 32943637
AN - SCOPUS:85091193081
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 4704
ER -