Abstract
To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant 'booster' response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 559-564 |
| Number of pages | 6 |
| Journal | International Journal of Leprosy |
| Volume | 53 |
| Issue number | 4 |
| State | Published - 1985 |
| Externally published | Yes |
ASJC Scopus subject areas
- Dermatology
Fingerprint
Dive into the research topics of 'A study of the immunological effects of cimetidine in patients with lepromatous leprosy'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS