A study of the immunological effects of cimetidine in patients with lepromatous leprosy

A. E. Brown; K. E. Nelson; S. Makonkawkeyoon; V. Vithayasai; D. M. Scollard; W. E. Bullock

A study of the immunological effects of cimetidine in patients with lepromatous leprosy

A. E. Brown, K. E. Nelson, S. Makonkawkeyoon, V. Vithayasai, D. M. Scollard, W. E. Bullock

Research output: Contribution to journal › Article › peer-review

Abstract

To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant 'booster' response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.

Original language	English (US)
Pages (from-to)	559-564
Number of pages	6
Journal	International Journal of Leprosy
Volume	53
Issue number	4
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Dermatology

Cite this

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title = "A study of the immunological effects of cimetidine in patients with lepromatous leprosy",

abstract = "To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant 'booster' response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.",

author = "Brown, {A. E.} and Nelson, {K. E.} and S. Makonkawkeyoon and V. Vithayasai and Scollard, {D. M.} and Bullock, {W. E.}",

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AU - Brown, A. E.

AU - Nelson, K. E.

AU - Makonkawkeyoon, S.

AU - Vithayasai, V.

AU - Scollard, D. M.

AU - Bullock, W. E.

PY - 1985

Y1 - 1985

N2 - To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant 'booster' response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.

AB - To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant 'booster' response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.

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A study of the immunological effects of cimetidine in patients with lepromatous leprosy

Abstract

ASJC Scopus subject areas

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