A SPECT camera for combined MRI and SPECT for small animals

D. Meier; D. J. Wagenaar; S. Chen; J. Xu; J. Yu; B. M.W. Tsui

doi:10.1016/j.nima.2010.09.116

A SPECT camera for combined MRI and SPECT for small animals

D. Meier, D. J. Wagenaar, S. Chen, J. Xu, J. Yu, B. M.W. Tsui

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a Ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI.

Original language	English (US)
Pages (from-to)	731-734
Number of pages	4
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	652
Issue number	1
DOIs	https://doi.org/10.1016/j.nima.2010.09.116
State	Published - Oct 1 2011

Keywords

MRI
Molecular imaging
Multi-modality imaging
SPECT

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/j.nima.2010.09.116

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title = "A SPECT camera for combined MRI and SPECT for small animals",

abstract = "We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a {\O}25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI.",

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author = "D. Meier and Wagenaar, {D. J.} and S. Chen and J. Xu and J. Yu and Tsui, {B. M.W.}",

note = "Funding Information: We thank A. El-Sharkawy, W. Edelstein for MRI work. We acknowledge support from the NIH ( R44 EB006712 and R01 EB008730 ), and the Norwegian Space Centre and the Research Council of Norway (VIT.01.06.1, BIA, 176973/I40).",

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AU - Meier, D.

AU - Wagenaar, D. J.

AU - Chen, S.

AU - Xu, J.

AU - Yu, J.

AU - Tsui, B. M.W.

N1 - Funding Information: We thank A. El-Sharkawy, W. Edelstein for MRI work. We acknowledge support from the NIH ( R44 EB006712 and R01 EB008730 ), and the Norwegian Space Centre and the Research Council of Norway (VIT.01.06.1, BIA, 176973/I40).

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N2 - We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a Ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI.

AB - We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a Ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI.

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KW - Molecular imaging

KW - Multi-modality imaging

KW - SPECT

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A SPECT camera for combined MRI and SPECT for small animals

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