Abstract
equation presented A 1% cross-linked divinylbenzene-polystyrene copolymer, containing cyanoethoxy N,N-diisopropylamine phosphine was prepared as a phosphitylating agent. The polymer-bound phosphitylated precursor was subjected to reaction with alcohols in the presence of 1H-tetrazole to produce the corresponding polymer-bound phosphite triesters. These were then oxidized with tert-butyl hydroperoxide to give the polymer-bound monophosphate triesters. Removal of cyanoethoxy on the resin with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) followed by basic cleavage of the p-hydroxybenzyl linker products yielded monophosphate derivatives.
Original language | English (US) |
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Pages (from-to) | 307-309 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - Jan 25 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine