A Simple Model of the Hemodynamic Effects of a Proximal Coronary Artery Narrowing

Edward H. Klopp; Vincent L. Gott

doi:10.1016/S0003-4975(10)64022-2

A Simple Model of the Hemodynamic Effects of a Proximal Coronary Artery Narrowing

Edward H. Klopp, Vincent L. Gott

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A simple mathematical model of the hemodynamic effects of a discrete proximal coronary artery obstruction is presented. The model demonstrates that resting myocardial flow demands fail to be met when the vessel diameter is decreased by 75% or greater. More strikingly, it shows that the maximum flow obtainable for increased myocardial oxygen demand begins to fall significantly with a lesion causing a 40 to 50% obstruction. The implications of these findings in relation to stress-induced angina are discussed.

Original language	English (US)
Pages (from-to)	309-312
Number of pages	4
Journal	Annals of Thoracic Surgery
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/S0003-4975(10)64022-2
State	Published - 1975

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/S0003-4975(10)64022-2

Cite this

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abstract = "A simple mathematical model of the hemodynamic effects of a discrete proximal coronary artery obstruction is presented. The model demonstrates that resting myocardial flow demands fail to be met when the vessel diameter is decreased by 75% or greater. More strikingly, it shows that the maximum flow obtainable for increased myocardial oxygen demand begins to fall significantly with a lesion causing a 40 to 50% obstruction. The implications of these findings in relation to stress-induced angina are discussed.",

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AB - A simple mathematical model of the hemodynamic effects of a discrete proximal coronary artery obstruction is presented. The model demonstrates that resting myocardial flow demands fail to be met when the vessel diameter is decreased by 75% or greater. More strikingly, it shows that the maximum flow obtainable for increased myocardial oxygen demand begins to fall significantly with a lesion causing a 40 to 50% obstruction. The implications of these findings in relation to stress-induced angina are discussed.

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A Simple Model of the Hemodynamic Effects of a Proximal Coronary Artery Narrowing

Abstract

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