A significant drug-drug interaction detected through corneal examination: Resolution of cornea verticillata while using amiodarone

Sonia Mehta; Vatinee Y. Bunya; Stephen E. Orlin; Michael E. Sulewski; Joshua L. Dunaief

doi:10.1097/ICO.0b013e3182107c8e

A significant drug-drug interaction detected through corneal examination: Resolution of cornea verticillata while using amiodarone

Sonia Mehta, Vatinee Y. Bunya, Stephen E. Orlin, Michael E. Sulewski, Joshua L. Dunaief

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: To describe a patient with resolution of cornea verticillata while still using amiodarone as a result of a drug interaction lowering serum levels of amiodarone.

Methods: An 83-year-old retired physician with long-standing cornea verticillata was noted to have complete resolution of cornea verticillata on a routine follow-up eye examination. The patient reported complete compliance with using amiodarone daily, with no recent changes in dosage or formulation. Despite this, he reported a recent increase in the frequency of palpitations. He had recently started rifampin for treatment of tuberculosis.

Results: Serum amiodarone and desethylamiodarone levels were obtained and found to be below therapeutic range. After rifampin was discontinued, serum amiodarone and desethylamiodarone levels increased to a therapeutic range and cornea verticillata returned after 4 months.

Conclusions: In patients currently using amiodarone, clearing of cornea verticillata should alert the ophthalmologists to the possibility of decreased serum amiodarone levels.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	Cornea
Volume	31
Issue number	1
DOIs	https://doi.org/10.1097/ICO.0b013e3182107c8e
State	Published - Jan 1 2012
Externally published	Yes

Keywords

Amiodarone
Amiodarone keratopathy
Cornea verticillata
Drug interaction
Isoniazid
Rifampin
Verticillate cornea
Vortex keratopathy

ASJC Scopus subject areas

Ophthalmology

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10.1097/ICO.0b013e3182107c8e

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title = "A significant drug-drug interaction detected through corneal examination: Resolution of cornea verticillata while using amiodarone",

abstract = "Purpose: To describe a patient with resolution of cornea verticillata while still using amiodarone as a result of a drug interaction lowering serum levels of amiodarone.Methods: An 83-year-old retired physician with long-standing cornea verticillata was noted to have complete resolution of cornea verticillata on a routine follow-up eye examination. The patient reported complete compliance with using amiodarone daily, with no recent changes in dosage or formulation. Despite this, he reported a recent increase in the frequency of palpitations. He had recently started rifampin for treatment of tuberculosis.Results: Serum amiodarone and desethylamiodarone levels were obtained and found to be below therapeutic range. After rifampin was discontinued, serum amiodarone and desethylamiodarone levels increased to a therapeutic range and cornea verticillata returned after 4 months.Conclusions: In patients currently using amiodarone, clearing of cornea verticillata should alert the ophthalmologists to the possibility of decreased serum amiodarone levels.",

keywords = "Amiodarone, Amiodarone keratopathy, Cornea verticillata, Drug interaction, Isoniazid, Rifampin, Verticillate cornea, Vortex keratopathy",

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T2 - Resolution of cornea verticillata while using amiodarone

AU - Mehta, Sonia

AU - Bunya, Vatinee Y.

AU - Orlin, Stephen E.

AU - Sulewski, Michael E.

AU - Dunaief, Joshua L.

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N2 - Purpose: To describe a patient with resolution of cornea verticillata while still using amiodarone as a result of a drug interaction lowering serum levels of amiodarone.Methods: An 83-year-old retired physician with long-standing cornea verticillata was noted to have complete resolution of cornea verticillata on a routine follow-up eye examination. The patient reported complete compliance with using amiodarone daily, with no recent changes in dosage or formulation. Despite this, he reported a recent increase in the frequency of palpitations. He had recently started rifampin for treatment of tuberculosis.Results: Serum amiodarone and desethylamiodarone levels were obtained and found to be below therapeutic range. After rifampin was discontinued, serum amiodarone and desethylamiodarone levels increased to a therapeutic range and cornea verticillata returned after 4 months.Conclusions: In patients currently using amiodarone, clearing of cornea verticillata should alert the ophthalmologists to the possibility of decreased serum amiodarone levels.

AB - Purpose: To describe a patient with resolution of cornea verticillata while still using amiodarone as a result of a drug interaction lowering serum levels of amiodarone.Methods: An 83-year-old retired physician with long-standing cornea verticillata was noted to have complete resolution of cornea verticillata on a routine follow-up eye examination. The patient reported complete compliance with using amiodarone daily, with no recent changes in dosage or formulation. Despite this, he reported a recent increase in the frequency of palpitations. He had recently started rifampin for treatment of tuberculosis.Results: Serum amiodarone and desethylamiodarone levels were obtained and found to be below therapeutic range. After rifampin was discontinued, serum amiodarone and desethylamiodarone levels increased to a therapeutic range and cornea verticillata returned after 4 months.Conclusions: In patients currently using amiodarone, clearing of cornea verticillata should alert the ophthalmologists to the possibility of decreased serum amiodarone levels.

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KW - Cornea verticillata

KW - Drug interaction

KW - Isoniazid

KW - Rifampin

KW - Verticillate cornea

KW - Vortex keratopathy

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A significant drug-drug interaction detected through corneal examination: Resolution of cornea verticillata while using amiodarone

Abstract

Keywords

ASJC Scopus subject areas

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