A shot of good cholesterol: Synthetic hdl, a new intervention for atherosclerosis

Sharon Dudley-Brown

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


One of the American Heart Association's Top 10 Research Advances for the Treatment of Heart Disease is the use of a synthetic form of high-density lipoprotein (HDL) to reduce coronary atherosclerosis (JAMA. 2003;290:2292-2300). While HDL has not been a target for therapy for dyslipidemias, new insight into the major protein component of HDL, apolipoprotein A-I, may lead to new therapies. Apolipoprotein A-I was recently found to be a better predictor of cardiovascular events than is low-density lipoprotein (Am Heart J. 2003;146:227-233; J Intern Med. 2004;255:188-205). This article reviews the recent study by Nissen and colleagues describing the finding of a genetic mutation in HDL in some persons in Italy and the subsequent development of a synthetic form of HDL to be used as an infusion to successfully target atherosclerotic lesions (JAMA. 2003;290:2292-2300). In addition, controversies related to HDL cholesterol as a target for therapy are reviewed. Implications for nursing research, education, and practice are also described.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalJournal of Cardiovascular Nursing
Issue number6
StatePublished - 2004
Externally publishedYes


  • ApoA-I Milano
  • Atherosclerosis
  • HDL

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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