A short, stereoselective, and common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its C-5 analogue

A. Ravi Kumar; N. Sudhakar; B. Venkateswara Rao; N. Raghunandan; A. Venkatesh; M. Sarangapani

doi:10.1016/j.bmcl.2005.02.059

A short, stereoselective, and common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its C-5 analogue

A. Ravi Kumar, N. Sudhakar, B. Venkateswara Rao, N. Raghunandan, A. Venkatesh, M. Sarangapani

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A short, stereoselective, and a common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its analogue using Evans protocol is described.

Original language	English (US)
Pages (from-to)	2085-2086
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2005.02.059
State	Published - Apr 15 2005
Externally published	Yes

Keywords

Chiral auxiliary
Cytotoxic activity
Evans-asymmetric aldol methodology
Tempo oxidation
δ-Lactones

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2005.02.059

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title = "A short, stereoselective, and common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its C-5 analogue",

abstract = "A short, stereoselective, and a common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its analogue using Evans protocol is described.",

keywords = "Chiral auxiliary, Cytotoxic activity, Evans-asymmetric aldol methodology, Tempo oxidation, δ-Lactones",

author = "Kumar, {A. Ravi} and N. Sudhakar and Rao, {B. Venkateswara} and N. Raghunandan and A. Venkatesh and M. Sarangapani",

note = "Funding Information: A.R.K. and N.S.R. thank CSIR and U.G.C. New Delhi, for their research fellowship. We also thank Dr. J. S. Yadav and Late Dr. A. K. Singh for their support and encouragement and Dr. S. Chandrasekhar for his help.",

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doi = "10.1016/j.bmcl.2005.02.059",

language = "English (US)",

volume = "15",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - A short, stereoselective, and common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its C-5 analogue

AU - Kumar, A. Ravi

AU - Sudhakar, N.

AU - Rao, B. Venkateswara

AU - Raghunandan, N.

AU - Venkatesh, A.

AU - Sarangapani, M.

N1 - Funding Information: A.R.K. and N.S.R. thank CSIR and U.G.C. New Delhi, for their research fellowship. We also thank Dr. J. S. Yadav and Late Dr. A. K. Singh for their support and encouragement and Dr. S. Chandrasekhar for his help.

PY - 2005/4/15

Y1 - 2005/4/15

N2 - A short, stereoselective, and a common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its analogue using Evans protocol is described.

AB - A short, stereoselective, and a common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its analogue using Evans protocol is described.

KW - Chiral auxiliary

KW - Cytotoxic activity

KW - Evans-asymmetric aldol methodology

KW - Tempo oxidation

KW - δ-Lactones

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AN - SCOPUS:15944418983

SN - 0960-894X

VL - 15

SP - 2085

EP - 2086

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

A short, stereoselective, and common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its C-5 analogue

Abstract

Keywords

ASJC Scopus subject areas

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