A role for immune complexes in enhanced respiratory syncytial virus disease

Fernando P. Polack; Michael N. Teng; Peter L. Collins; Gregory A. Prince; Marcus Exner; Heinz Regele; Dario D. Lirman; Richard Rabold; Scott J. Hoffman; Christopher L. Karp; Steven R. Kleeberger; Marsha Wills-Karp; Ruth A. Karron

doi:10.1084/jem.20020781

A role for immune complexes in enhanced respiratory syncytial virus disease

Fernando P. Polack, Michael N. Teng, Peter L. Collins, Gregory A. Prince, Marcus Exner, Heinz Regele, Dario D. Lirman, Richard Rabold, Scott J. Hoffman, Christopher L. Karp, Steven R. Kleeberger, Marsha Wills-Karp, Ruth A. Karron

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

248 Scopus citations

Abstract

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.

Original language	English (US)
Pages (from-to)	859-865
Number of pages	7
Journal	Journal of Experimental Medicine
Volume	196
Issue number	6
DOIs	https://doi.org/10.1084/jem.20020781
State	Published - Sep 16 2002

Keywords

Airway hyperresponsiveness
Compliment
Enhanced disease
Immune complexes
Respiratory syncytial virus

ASJC Scopus subject areas

General Medicine

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10.1084/jem.20020781

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title = "A role for immune complexes in enhanced respiratory syncytial virus disease",

abstract = "Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.",

keywords = "Airway hyperresponsiveness, Compliment, Enhanced disease, Immune complexes, Respiratory syncytial virus",

author = "Polack, {Fernando P.} and Teng, {Michael N.} and Collins, {Peter L.} and Prince, {Gregory A.} and Marcus Exner and Heinz Regele and Lirman, {Dario D.} and Richard Rabold and Hoffman, {Scott J.} and Karp, {Christopher L.} and Kleeberger, {Steven R.} and Marsha Wills-Karp and Karron, {Ruth A.}",

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AU - Polack, Fernando P.

AU - Teng, Michael N.

AU - Collins, Peter L.

AU - Prince, Gregory A.

AU - Exner, Marcus

AU - Regele, Heinz

AU - Lirman, Dario D.

AU - Rabold, Richard

AU - Hoffman, Scott J.

AU - Karp, Christopher L.

AU - Kleeberger, Steven R.

AU - Wills-Karp, Marsha

AU - Karron, Ruth A.

PY - 2002/9/16

Y1 - 2002/9/16

N2 - Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.

AB - Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.

KW - Airway hyperresponsiveness

KW - Compliment

KW - Enhanced disease

KW - Immune complexes

KW - Respiratory syncytial virus

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A role for immune complexes in enhanced respiratory syncytial virus disease

Abstract

Keywords

ASJC Scopus subject areas

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