A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma

Emily Wyse, James T. Handa, Alan D. Friedman, Monica S. Pearl

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Retinoblastoma is a malignancy of the retina that usually presents before the age of 5 years. Sporadic retinoblastoma is most often unilateral and with no hereditary influence, whereas familial retinoblastoma presents unilaterally or bilaterally in conjunction with genetic inheritance. Several treatments have been attempted with the goals of saving the child’s life, salvaging the eye, and preserving vision. Alternative methods including external beam radiation, systemic chemotherapy and focal therapies have been shown to be effective but carry a risk of enucleation and other complications proportional to the severity of the tumor. Selective intra-arterial chemotherapy for retinoblastoma began in 1988 in Japan and has emerged in the last 7 years in the United States as a feasible, effective and minimally invasive treatment option. We review the retinoblastoma treatment literature focusing on intra-arterial chemotherapy.

Original languageEnglish (US)
Pages (from-to)1223-1233
Number of pages11
JournalPediatric radiology
Issue number9
StatePublished - Aug 1 2016


  • Children
  • International classification
  • Intra-arterial chemotherapy
  • Melphalan
  • Reese–Ellsworth classification
  • Retinoblastoma
  • Systemic chemotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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