A restraint-free small animal SPECT imaging system with motion tracking

A. G. Weisenberger, S. S. Gleason, J. Goddard, B. Kross, S. Majewski, S. R. Meikle, M. J. Paulus, M. Pomper, V. Popov, M. F. Smith, B. L. Welch, R. Wojcik

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels while retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.

Original languageEnglish (US)
Pages (from-to)638-644
Number of pages7
JournalIEEE Transactions on Nuclear Science
Issue number3 I
StatePublished - Jun 2005


  • Motion tracking
  • Multimodality imaging
  • Small animal single photon emission computed tomography (SPECT)

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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