TY - JOUR
T1 - A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases
T2 - A case report and review of the literature
AU - Keenan, Camille
AU - Ramirez, Nicole
AU - Elijovich, Lucas
AU - Klimo, Paul
AU - Bag, Asim K.
AU - Acharya, Sahaja
AU - Upadhyaya, Santhosh A.
N1 - Funding Information:
The authors gratefully acknowledge Angela McArthur, PhD for her scientific editing of the manuscript. This work was supported by grant CA21765 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This study was also supported by the American Lebanese Syrian Associated Charities (ALSAC).
Publisher Copyright:
© 2021 Wiley Periodicals LLC
PY - 2021/6
Y1 - 2021/6
N2 - Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra-CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.
AB - Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra-CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.
KW - arteriovenous fistula
KW - choriocarcinoma syndrome
KW - metastatic intracranial germ cell tumor
KW - serum beta-hCG
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U2 - 10.1002/pbc.29000
DO - 10.1002/pbc.29000
M3 - Article
C2 - 33818876
AN - SCOPUS:85103877076
SN - 1545-5009
VL - 68
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 6
M1 - e29000
ER -