A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Jennifer A. Deal; Marilyn S. Albert; Michelle Arnold; Shrikant I. Bangdiwala; Theresa Chisolm; Sonia Davis; Ann Eddins; Nancy W. Glynn; Adele M. Goman; Melissa Minotti; Thomas Mosley; George W. Rebok; Nicholas Reed; Elizabeth Rodgers; Victoria Sanchez; A. Richey Sharrett; Josef Coresh; Frank R. Lin

doi:10.1016/j.trci.2017.06.003

A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Jennifer A. Deal, Marilyn S. Albert, Michelle Arnold, Shrikant I. Bangdiwala, Theresa Chisolm, Sonia Davis, Ann Eddins, Nancy W. Glynn, Adele M. Goman, Melissa Minotti, Thomas Mosley, George W. Rebok, Nicholas Reed, Elizabeth Rodgers, Victoria Sanchez, A. Richey Sharrett, Josef Coresh, Frank R. Lin

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Introduction Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

Original language	English (US)
Pages (from-to)	410-415
Number of pages	6
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/j.trci.2017.06.003
State	Published - Sep 2017

Keywords

Clinical trials
Cognition
Dementia
Epidemiology
Hearing
Longitudinal study
Memory
Presbycusis

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.trci.2017.06.003

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Deal, J. A., Albert, M. S., Arnold, M., Bangdiwala, S. I., Chisolm, T., Davis, S., Eddins, A., Glynn, N. W., Goman, A. M., Minotti, M., Mosley, T., Rebok, G. W., Reed, N., Rodgers, E., Sanchez, V., Sharrett, A. R., Coresh, J., & Lin, F. R. (2017). A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(3), 410-415. https://doi.org/10.1016/j.trci.2017.06.003

A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study. / Deal, Jennifer A.; Albert, Marilyn S.; Arnold, Michelle et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 3, No. 3, 09.2017, p. 410-415.

Research output: Contribution to journal › Article › peer-review

Deal, JA , Albert, MS, Arnold, M, Bangdiwala, SI, Chisolm, T, Davis, S, Eddins, A, Glynn, NW, Goman, AM, Minotti, M, Mosley, T, Rebok, GW , Reed, N, Rodgers, E, Sanchez, V, Sharrett, AR, Coresh, J & Lin, FR 2017, 'A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 3, pp. 410-415. https://doi.org/10.1016/j.trci.2017.06.003

Deal JA , Albert MS, Arnold M, Bangdiwala SI, Chisolm T, Davis S et al. A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2017 Sep;3(3):410-415. doi: 10.1016/j.trci.2017.06.003

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title = "A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study",

abstract = "Introduction Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.",

keywords = "Clinical trials, Cognition, Dementia, Epidemiology, Hearing, Longitudinal study, Memory, Presbycusis",

author = "Deal, {Jennifer A.} and Albert, {Marilyn S.} and Michelle Arnold and Bangdiwala, {Shrikant I.} and Theresa Chisolm and Sonia Davis and Ann Eddins and Glynn, {Nancy W.} and Goman, {Adele M.} and Melissa Minotti and Thomas Mosley and Rebok, {George W.} and Nicholas Reed and Elizabeth Rodgers and Victoria Sanchez and Sharrett, {A. Richey} and Josef Coresh and Lin, {Frank R.}",

note = "Funding Information: The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study was supported by National Institute on Aging 1R34AG046548-01A1 and the Eleanor Schwartz Charitable Foundation. The Atherosclerosis Risk in Communities Study (ARIC) is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). Neurocognitive data are collected by U01 HL096812, HL096814, HL096899, HL096902, HL096917, with previous brain magnetic resonance imaging examinations funded by R01-HL70825 and additional support from the National Institutes of Neurological Disorders and Stroke. The authors thank the staff and participants of the ARIC study for their important contributions. Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = sep,

doi = "10.1016/j.trci.2017.06.003",

language = "English (US)",

volume = "3",

pages = "410--415",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

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T1 - A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline

T2 - Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

AU - Deal, Jennifer A.

AU - Albert, Marilyn S.

AU - Arnold, Michelle

AU - Bangdiwala, Shrikant I.

AU - Chisolm, Theresa

AU - Davis, Sonia

AU - Eddins, Ann

AU - Glynn, Nancy W.

AU - Goman, Adele M.

AU - Minotti, Melissa

AU - Mosley, Thomas

AU - Rebok, George W.

AU - Reed, Nicholas

AU - Rodgers, Elizabeth

AU - Sanchez, Victoria

AU - Sharrett, A. Richey

AU - Coresh, Josef

AU - Lin, Frank R.

N1 - Funding Information: The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study was supported by National Institute on Aging 1R34AG046548-01A1 and the Eleanor Schwartz Charitable Foundation. The Atherosclerosis Risk in Communities Study (ARIC) is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). Neurocognitive data are collected by U01 HL096812, HL096814, HL096899, HL096902, HL096917, with previous brain magnetic resonance imaging examinations funded by R01-HL70825 and additional support from the National Institutes of Neurological Disorders and Stroke. The authors thank the staff and participants of the ARIC study for their important contributions. Publisher Copyright: © 2017 The Authors

PY - 2017/9

Y1 - 2017/9

N2 - Introduction Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

AB - Introduction Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

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KW - Cognition

KW - Dementia

KW - Epidemiology

KW - Hearing

KW - Longitudinal study

KW - Memory

KW - Presbycusis

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A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

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Keywords

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