A randomized comparison study of drop versus spray topical cycloplegic application

C. R. Goodman, D. G. Hunter, M. X. Repka

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: To evaluate the acceptance of ocular spray administration. Methods: A randomized, single-masked comparison in a cohort of children from 3 to 13 years. Assessment of patient pain was recorded on a visual analog scale. Cycloplegia was assessed by an ophthalmologist masked to the assignment. A questionnaire was used to assess patient acceptance. 126 patient participated. The average age was 7.7 years for spray, 7.1 for drops. Results: Pain (higher number = more painful): means: 41/100 for spray; 35/100 for drops (P=0.28). No difference in cycloplegia noted (i.e., satisfactory in all subjects). Subjective acceptance: high in both patient groups, but a preference for spray was noted (P=0.06). No untoward drug reactions occurred with either method. Conclusions: Cycloplegia spray was as acceptable, or more acceptable than drops. Cycloplegia was comparable for the two methods. Spray application of cycloplegia drugs is a satisfactory route of topical administration for children.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalBinocular Vision and Strabismus Quarterly
Issue number2
StatePublished - Jul 21 1999


  • Administration, pharmacologic
  • Cycloplegia
  • Drop application
  • Pain evaluation
  • Prospective study
  • Route, medication
  • Spray application
  • Topical administration
  • Visual analog scale

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'A randomized comparison study of drop versus spray topical cycloplegic application'. Together they form a unique fingerprint.

Cite this