A quick look at slow saccades after cardiac surgery: where is the lesion?

David Solomon, Stefano Ramat, R. John Leigh, David Zee

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Saccadic palsy is a reported complication of cardiac surgery. One case that came to autopsy showed midline pontine gliosis; however, in most cases, no lesions are evident on neuroimaging. Since the saccadic palsy may range from single large slow saccades to a "staircase" of very small saccades that are normal in speed, it seems plausible that more than one mechanism is possible. Here we postulate that, in those patients who make a staircase of small saccades, loss of cerebellar Purkinje cells could cause fastigial nucleus neurons to fire prematurely, thereby decelerating saccades via inhibitory burst neurons.

Original languageEnglish (US)
Title of host publicationUsing Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever
Number of pages4
ISBN (Print)9780444531636
StatePublished - 2008

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123


  • Purkinje cells
  • excitatory burst neuron
  • fastigial nucleus
  • inhibitory burst neuron
  • omnipause neurons
  • saccades
  • saccadic hypometria
  • saccadic palsy

ASJC Scopus subject areas

  • Neuroscience(all)


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