Abstract
Simian immunodeficiency virus (SIV) infection in macaques is so far the best animal model for human immunodeficiency virus type 1 (HIV-1) studies, but suppressing viral replication in infected animals remains challenging. Using a novel single-round infectivity assay, we quantitated the antiviral activities of antiretroviral drugs against SIV. Our results emphasize the importance of the dose-response curve slope in determining the inhibitory potential of antiretroviral drugs and provide useful information for regimen selection in treating SIV-infected animals in models of therapy and virus eradication.
Original language | English (US) |
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Pages (from-to) | 11368-11372 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 86 |
Issue number | 20 |
DOIs | |
State | Published - Oct 2012 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology