A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling

Jon H. Chung; Andrew R. Larsen; Evan Chen; Fred Bunz

doi:10.1074/jbc.M114.597203

A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling

Jon H. Chung, Andrew R. Larsen, Evan Chen, Fred Bunz

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: p53 activates transcription of downstream target genes that contribute to tumor suppression. Results: The expression of PTCH53, a structural and functional homolog of PTCH1, is highly responsive to p53 in diverse cells and tissues. Conclusion: p53 can suppress canonical Hedgehog signaling via induction of PTCH53.Significance: PTCH53 is a new mediator by which p53 can suppress oncogenic Hedgehog signals.

Original language	English (US)
Pages (from-to)	33020-33031
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M114.597203
State	Published - Nov 21 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling",

abstract = "Background: p53 activates transcription of downstream target genes that contribute to tumor suppression. Results: The expression of PTCH53, a structural and functional homolog of PTCH1, is highly responsive to p53 in diverse cells and tissues. Conclusion: p53 can suppress canonical Hedgehog signaling via induction of PTCH53.Significance: PTCH53 is a new mediator by which p53 can suppress oncogenic Hedgehog signals.",

author = "Chung, {Jon H.} and Larsen, {Andrew R.} and Evan Chen and Fred Bunz",

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AU - Chung, Jon H.

AU - Larsen, Andrew R.

AU - Chen, Evan

AU - Bunz, Fred

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AB - Background: p53 activates transcription of downstream target genes that contribute to tumor suppression. Results: The expression of PTCH53, a structural and functional homolog of PTCH1, is highly responsive to p53 in diverse cells and tissues. Conclusion: p53 can suppress canonical Hedgehog signaling via induction of PTCH53.Significance: PTCH53 is a new mediator by which p53 can suppress oncogenic Hedgehog signals.

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A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling

Abstract

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