TY - JOUR
T1 - A protein taxonomy based on secondary structure
AU - Przytycka, Teresa
AU - Aurora, Rajeev
AU - Rose, George D.
N1 - Funding Information:
We thank R. Srinivasan, V. Murthy and P. Thiessen for helpful suggestions, and J. Cohen for providing access to his tree-construction program, Tande. We are particularly indebted to an anonymous referee for assistance in bringing this paper to fruition. Supported by the Sloan Foundation (T.P.) and the NIH (G.D.R.).
PY - 1999
Y1 - 1999
N2 - Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves, our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.
AB - Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves, our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.
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U2 - 10.1038/10728
DO - 10.1038/10728
M3 - Article
C2 - 10404226
AN - SCOPUS:0033056948
SN - 1072-8368
VL - 6
SP - 672
EP - 682
JO - Nature Structural Biology
JF - Nature Structural Biology
IS - 7
ER -