TY - JOUR
T1 - A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers
AU - Lim, Unhee
AU - Freedmam, D. Michal
AU - HoIIis, Bruce W.
AU - Horst, Ronald L.
AU - Purdue, Mark P.
AU - Chatterjee, Nilanjan
AU - Weinstein, Stephanie J.
AU - Morton, Lindsay M.
AU - Schatzkin, Arthur
AU - Virtamo, Jarmo
AU - Linet, Martha S.
AU - Hartge, Patricia
AU - Albanes, Demetrius
PY - 2009/2/15
Y1 - 2009/2/15
N2 - Studies indicate that higher sun exposure, especially in the recent past, is associated with reduced risk of non-Hodgkin lymphoma (NHL). Ultraviolet radiation-derived vitamin D may be protective against lymphomagenesis. We examined the relationship between prediagnostic serum 25-hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort (1985-2002) of 29,133 Finnish male smokers (ages 50-69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth-year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95% conidence interval (CI), 0.50,1.14) and 0.82 (95% CI, 0.53,1.26). The 25(OH)D-NHL association, however, differed by follow-up duration at diagnosis. Cases diagnosed less than 7 years from the baseline showed an inverse association (OR for highest vs. lowest tertile = 0.43; 95% CI: 0.23, 0.S3; p for trend = 0.01), but not later diagnoses (OR = 1.52; 95% CI: 0.82, 2.80; p for trend = 0.17). The inverse association found for close exposure to diagnosis was not confounded by other risk factors for lymphoma or correlates of 25(OH)D. Although our findings suggest that circulating 25(OH)D is not likely associated with overall lymphoid cancer, they indicate a potentially protective effect on short-term risk of NHL.
AB - Studies indicate that higher sun exposure, especially in the recent past, is associated with reduced risk of non-Hodgkin lymphoma (NHL). Ultraviolet radiation-derived vitamin D may be protective against lymphomagenesis. We examined the relationship between prediagnostic serum 25-hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort (1985-2002) of 29,133 Finnish male smokers (ages 50-69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth-year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95% conidence interval (CI), 0.50,1.14) and 0.82 (95% CI, 0.53,1.26). The 25(OH)D-NHL association, however, differed by follow-up duration at diagnosis. Cases diagnosed less than 7 years from the baseline showed an inverse association (OR for highest vs. lowest tertile = 0.43; 95% CI: 0.23, 0.S3; p for trend = 0.01), but not later diagnoses (OR = 1.52; 95% CI: 0.82, 2.80; p for trend = 0.17). The inverse association found for close exposure to diagnosis was not confounded by other risk factors for lymphoma or correlates of 25(OH)D. Although our findings suggest that circulating 25(OH)D is not likely associated with overall lymphoid cancer, they indicate a potentially protective effect on short-term risk of NHL.
KW - 25-hydroxyvitamin D
KW - Diet
KW - Lymphoid neoplasms
KW - Nested case-control studies
KW - Non-Hodgkin lymphoma
KW - Vitamin D
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U2 - 10.1002/ijc.23984
DO - 10.1002/ijc.23984
M3 - Article
C2 - 19035445
AN - SCOPUS:58149468080
SN - 0020-7136
VL - 124
SP - 979
EP - 986
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 4
ER -