Abstract
Background: Concerns remain regarding whether oral antibiotic or isotretinoin use for acne is associated with increased risk of inflammatory bowel disease (IBD); little is known about whether acne itself is associated with IBD. Objective: To determine whether isotretinoin exposure, oral tetracycline-class antibiotic exposure, and/or acne itself are associated with IBD. Methods: A propensity score matched cohort study was performed using TriNetX between 2001 and 2022 to compare the 1-year incidence of IBD between those without acne compared to those with acne managed without systemic medications, acne managed with oral tetracycline-class antibiotics, and acne managed with isotretinoin. Results: There was a statistically significant association between acne and risk of incident IBD (odds ratio: 1.42; 95% confidence interval: 1.23-1.65). There was no statistically significant association between oral tetracycline-class antibiotic or isotretinoin exposure and IBD. Limitations: Use of electronic health data; potential for misclassification bias. Conclusion: This matched cohort study identifies an association between acne and IBD. These data provide further reassurance regarding the use of isotretinoin in the treatment of acne.
Original language | English (US) |
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Pages (from-to) | 841-847 |
Number of pages | 7 |
Journal | Journal of the American Academy of Dermatology |
Volume | 88 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2023 |
Keywords
- Crohn's disease
- acne
- doxycycline
- inflammatory bowel disease
- isotretinoin
- minocycline
- tetracyclines
- ulcerative colitis
ASJC Scopus subject areas
- Dermatology