A practical evidence-based approach to rhinosinusitis

Antoine E. Azar, Barbara A. Muller

Research output: Contribution to journalReview articlepeer-review


Rhinosinusitis affects millions of persons annually and has a marked impact on quality of life and work productivity. Chronic rhinosinusitis (CRS) is characterized by symptoms that last at least 12 weeks. The history and physical examination should include a search for underlying conditions, such as allergic or nonallergic rhinitis and nasal polyposis. An evaluation of underlying immunodeficiency is warranted in certain patients, particularly those with severe or difficult-to-treat disease or other recurrent infections. When radiologic evaluation is indicated, coronal sinus CT scanning is the procedure of choice. While antibiotics are indicated for bacterial rhinosinusitis, intranasal corticosteroids represent the mainstay of treatment for CRS and are particularly useful when polyp disease is present. Nasal irrigation with a saline solution can be a very beneficial adjunctive therapy. Depending on coexisting conditions, additional treatments may include antihistamines, leukotriene modifiers, and immunotherapy.

Original languageEnglish (US)
Pages (from-to)372-379
Number of pages8
JournalJournal of Respiratory Diseases
Issue number9
StatePublished - Sep 2006
Externally publishedYes


  • Rhinitis
  • Sinusitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'A practical evidence-based approach to rhinosinusitis'. Together they form a unique fingerprint.

Cite this