A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors

Alexandre Iannello; Suzanne Samarani; Ossama Allam; Mohammad Ali Jenabian; Vikram Mehraj; Devendra Amre; Jean Pierre Routy; Cécile Tremblay; Ali Ahmad

doi:10.1016/j.cyto.2016.10.018

A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors

Alexandre Iannello, Suzanne Samarani, Ossama Allam, Mohammad Ali Jenabian, Vikram Mehraj, Devendra Amre, Jean Pierre Routy, Cécile Tremblay, Ali Ahmad

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.

Original language	English (US)
Pages (from-to)	96-99
Number of pages	4
Journal	Cytokine
Volume	90
DOIs	https://doi.org/10.1016/j.cyto.2016.10.018
State	Published - Feb 1 2017

Keywords

AIDS
HIV-1
IL-18
IL-18BP
Long-Term Non-Progressors

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

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10.1016/j.cyto.2016.10.018

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title = "A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors",

abstract = "An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.",

keywords = "AIDS, HIV-1, IL-18, IL-18BP, Long-Term Non-Progressors",

author = "Alexandre Iannello and Suzanne Samarani and Ossama Allam and Jenabian, {Mohammad Ali} and Vikram Mehraj and Devendra Amre and Routy, {Jean Pierre} and C{\'e}cile Tremblay and Ali Ahmad",

note = "Funding Information: We thank Mr. Mario Legault, Project Director AIDS & Infectious Diseases{\textquoteright} Network, FRSQ, for administrative coordination in procuring blood samples from HIV-infected individuals, to the virus-infected and healthy individuals for the samples. AI was supported by a scholarship from the FRSQ. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

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doi = "10.1016/j.cyto.2016.10.018",

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AU - Iannello, Alexandre

AU - Samarani, Suzanne

AU - Allam, Ossama

AU - Jenabian, Mohammad Ali

AU - Mehraj, Vikram

AU - Amre, Devendra

AU - Routy, Jean Pierre

AU - Tremblay, Cécile

AU - Ahmad, Ali

N1 - Funding Information: We thank Mr. Mario Legault, Project Director AIDS & Infectious Diseases’ Network, FRSQ, for administrative coordination in procuring blood samples from HIV-infected individuals, to the virus-infected and healthy individuals for the samples. AI was supported by a scholarship from the FRSQ. Publisher Copyright: © 2016 Elsevier Ltd

PY - 2017/2/1

Y1 - 2017/2/1

N2 - An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.

AB - An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.

KW - AIDS

KW - HIV-1

KW - IL-18

KW - IL-18BP

KW - Long-Term Non-Progressors

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JO - Cytokine

JF - Cytokine

ER -

A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors

Abstract

Keywords

ASJC Scopus subject areas

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