A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli

Fred A. Lenz; Richard H. Gracely; Lance H. Rowland; Patrick M. Dougherty

doi:10.1016/0304-3940(94)90910-5

A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli

Fred A. Lenz, Richard H. Gracely, Lance H. Rowland, Patrick M. Dougherty

School of Medicine

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

A population of neurons located in the cutaneous core of the principal sensory nucleus of human thalamus (ventralis caudalis, Vc) has been identified that had their maximal response to mechanical stimuli which were perceived as painful by the patients involved. None of these cells responded to painful thermal stimuli. The graded responses of these cells to mechanical stimuli extending into the painful range suggest they both mediate acute pain in response to mechanical stimuli and participate in mechanical hyperalgesia.

Original language	English (US)
Pages (from-to)	46-50
Number of pages	5
Journal	Neuroscience Letters
Volume	180
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)90910-5
State	Published - Oct 10 1994

Keywords

Human
Neurophysiology
Nociception
Pain measurement
Ventral posterior thalamic nucleus

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)90910-5

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title = "A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli",

abstract = "A population of neurons located in the cutaneous core of the principal sensory nucleus of human thalamus (ventralis caudalis, Vc) has been identified that had their maximal response to mechanical stimuli which were perceived as painful by the patients involved. None of these cells responded to painful thermal stimuli. The graded responses of these cells to mechanical stimuli extending into the painful range suggest they both mediate acute pain in response to mechanical stimuli and participate in mechanical hyperalgesia.",

keywords = "Human, Neurophysiology, Nociception, Pain measurement, Ventral posterior thalamic nucleus",

author = "Lenz, {Fred A.} and Gracely, {Richard H.} and Rowland, {Lance H.} and Dougherty, {Patrick M.}",

note = "Funding Information: Supported by grants to FAL from the Eli Lilly Corporation and the NIH (NS28598, K08-NS1384, P01-NS32386-01).",

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AU - Lenz, Fred A.

AU - Gracely, Richard H.

AU - Rowland, Lance H.

AU - Dougherty, Patrick M.

N1 - Funding Information: Supported by grants to FAL from the Eli Lilly Corporation and the NIH (NS28598, K08-NS1384, P01-NS32386-01).

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Y1 - 1994/10/10

N2 - A population of neurons located in the cutaneous core of the principal sensory nucleus of human thalamus (ventralis caudalis, Vc) has been identified that had their maximal response to mechanical stimuli which were perceived as painful by the patients involved. None of these cells responded to painful thermal stimuli. The graded responses of these cells to mechanical stimuli extending into the painful range suggest they both mediate acute pain in response to mechanical stimuli and participate in mechanical hyperalgesia.

AB - A population of neurons located in the cutaneous core of the principal sensory nucleus of human thalamus (ventralis caudalis, Vc) has been identified that had their maximal response to mechanical stimuli which were perceived as painful by the patients involved. None of these cells responded to painful thermal stimuli. The graded responses of these cells to mechanical stimuli extending into the painful range suggest they both mediate acute pain in response to mechanical stimuli and participate in mechanical hyperalgesia.

KW - Human

KW - Neurophysiology

KW - Nociception

KW - Pain measurement

KW - Ventral posterior thalamic nucleus

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A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli

Abstract

Keywords

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