A pivotal role for p53: Balancing aerobic respiration and glycolysis

Wenzhe Ma; Ho Joong Sung; Joon Y. Park; Satoaki Matoba; Paul M. Hwang

doi:10.1007/s10863-007-9083-0

A pivotal role for p53: Balancing aerobic respiration and glycolysis

Wenzhe Ma, Ho Joong Sung, Joon Y. Park, Satoaki Matoba, Paul M. Hwang

Research output: Contribution to journal › Short survey › peer-review

109 Scopus citations

Abstract

The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.

Original language	English (US)
Pages (from-to)	243-246
Number of pages	4
Journal	Journal of Bioenergetics and Biomembranes
Volume	39
Issue number	3
DOIs	https://doi.org/10.1007/s10863-007-9083-0
State	Published - Jun 2007
Externally published	Yes

Keywords

Cytochrome c oxidase
Synthesis of cytochrome c oxidase 2
Tumor protein p53

ASJC Scopus subject areas

Physiology
Cell Biology

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10.1007/s10863-007-9083-0

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title = "A pivotal role for p53: Balancing aerobic respiration and glycolysis",

abstract = "The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.",

keywords = "Cytochrome c oxidase, Synthesis of cytochrome c oxidase 2, Tumor protein p53",

author = "Wenzhe Ma and Sung, {Ho Joong} and Park, {Joon Y.} and Satoaki Matoba and Hwang, {Paul M.}",

note = "Funding Information: Acknowledgements We thank members of the laboratory, Toren Finkel and Michael N. Sack for critical reading of this manuscript. This work was supported by the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH.",

year = "2007",

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T2 - Balancing aerobic respiration and glycolysis

AU - Ma, Wenzhe

AU - Sung, Ho Joong

AU - Park, Joon Y.

AU - Matoba, Satoaki

AU - Hwang, Paul M.

N1 - Funding Information: Acknowledgements We thank members of the laboratory, Toren Finkel and Michael N. Sack for critical reading of this manuscript. This work was supported by the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH.

PY - 2007/6

Y1 - 2007/6

N2 - The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.

AB - The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.

KW - Cytochrome c oxidase

KW - Synthesis of cytochrome c oxidase 2

KW - Tumor protein p53

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DO - 10.1007/s10863-007-9083-0

M3 - Short survey

C2 - 17551815

AN - SCOPUS:35448940790

SN - 0145-479X

VL - 39

SP - 243

EP - 246

JO - Journal of Bioenergetics and Biomembranes

JF - Journal of Bioenergetics and Biomembranes

IS - 3

ER -

A pivotal role for p53: Balancing aerobic respiration and glycolysis

Abstract

Keywords

ASJC Scopus subject areas

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