A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarity

Robert L. Findling, Jacqui Lingler, Brieana M. Rowles, Nora K. McNamara, Joseph R. Calabrese

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Children and adolescents who are the offspring of a bipolar parent and who first present with major depressive disorder (MDD) are at high risk for eventually developing bipolar disorder. In this report, the authors describe a group of 9 such high-risk children and adolescents with MDD, aged 7-16 years, who were randomized to receive treatment with either paroxetine monotherapy or combination paroxetine-divalproex sodium therapy. In the long-term management of depressive symptomatology in these patients, neither treatment appeared to be particularly effective. As a result, future treatment studies in this population appear to be warranted, not only due to the putative impending risk of developing bipolar disorder, but also the manifest risk of current depressive episodes.

Original languageEnglish (US)
Pages (from-to)615-621
Number of pages7
JournalJournal of child and adolescent psychopharmacology
Issue number6
StatePublished - Dec 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)


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