Abstract
This study explores the imaging and therapeutic properties of a novel radiopharmaceutical, 131I-CLR1404. Phase 1a data demonstrated safety and tumor localization by SPECT-CT. This 1b study assessed safety, imaging characteristics, and possible antineoplastic properties and provided further proof-of- concept of phospholipid ether analogues retention within tumors. A total of 10 patients received 131I-CLR1404 in an adaptive dose-escalation design. Imaging characteristics were consistent with prior studies, showing tumor uptake in primary tumors and metastases. At doses of 31.25 mCi/m2 and greater, DLTs were thrombocytopenia and neutropenia. Disease- specific studies are underway to identify cancers most likely to benefit from 131I-CLR1404 monotherapy.
Original language | English (US) |
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Pages (from-to) | 483-489 |
Number of pages | 7 |
Journal | Cancer Investigation |
Volume | 33 |
Issue number | 10 |
DOIs | |
State | Published - Nov 26 2015 |
Externally published | Yes |
Keywords
- Drug discovery
- Phase 1
- Radiotherapy
- Targeted therapy
ASJC Scopus subject areas
- Oncology
- Cancer Research