TY - JOUR
T1 - A novel signaling pathway from rod photoreceptors to ganglion cells in mammalian retina
AU - Soucy, Ed
AU - Wang, Yanshu
AU - Nirenberg, Sheila
AU - Nathans, Jeremy
AU - Meister, Markus
N1 - Funding Information:
Thanks to Alexander Dizhoor for anti-recoverin antibodies and to Hui Sun, David Caulkins, and Stewart Hendry for helpful advice. This work was supported by a Pew Scholarship and a Presidential Faculty Fellows Award (M. M.), a National Research Service Award (S. N.), and the National Eye Institute (National Institutes of Health) and the Howard Hughes Medical Institute (J. N.).
PY - 1998/9
Y1 - 1998/9
N2 - Current understanding suggests that mammalian rod photoreceptors connect only to an ON-type bipolar cell. This rod-specific bipolar cell excites the All amacrine cell, which makes connections to cone-specific bipolar cells of both ON and OFF type; these, in turn, synapse with ganglion cells. Recent work on rabbit retina has shown that rod signals can also reach ganglion cells without passing through the rod bipolar cell. This route was thought to be provided by electrical gap junctions, through which rods signal directly to cones and thence to cone bipolar cells. Here, we show that the mouse retina also provides a rod pathway bypassing the rod bipolar cell, suggesting that this is a common feature in mammals. However, this alternative pathway does not require cone photoreceptors; it is perfectly intact in a transgenic mouse whose retina lacks cones. Instead, the results can be explained if rods connect directly to OFF bipolar cells.
AB - Current understanding suggests that mammalian rod photoreceptors connect only to an ON-type bipolar cell. This rod-specific bipolar cell excites the All amacrine cell, which makes connections to cone-specific bipolar cells of both ON and OFF type; these, in turn, synapse with ganglion cells. Recent work on rabbit retina has shown that rod signals can also reach ganglion cells without passing through the rod bipolar cell. This route was thought to be provided by electrical gap junctions, through which rods signal directly to cones and thence to cone bipolar cells. Here, we show that the mouse retina also provides a rod pathway bypassing the rod bipolar cell, suggesting that this is a common feature in mammals. However, this alternative pathway does not require cone photoreceptors; it is perfectly intact in a transgenic mouse whose retina lacks cones. Instead, the results can be explained if rods connect directly to OFF bipolar cells.
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U2 - 10.1016/S0896-6273(00)80560-7
DO - 10.1016/S0896-6273(00)80560-7
M3 - Article
C2 - 9768836
AN - SCOPUS:0032168084
SN - 0896-6273
VL - 21
SP - 481
EP - 493
JO - Neuron
JF - Neuron
IS - 3
ER -