A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging: Vasoconstriction during reduced shear

Harrya A. Silber; Pamela Ouyang; David A. Bluemke; Sandeep N. Gupta; Thomas K. Foo; Joao A.C. Lima

doi:10.1081/JCMR-200065578

A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging: Vasoconstriction during reduced shear

Harrya A. Silber, Pamela Ouyang, David A. Bluemke, Sandeep N. Gupta, Thomas K. Foo, Joao A.C. Lima

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We investigated whether endothelial-dependent arterial constriction during reduced shear can be measured using phase contrast magnetic resonance imaging (PCMRI). A cross-section of the femoral artery was acquired during a 5-minute distal occlusion in 33 subjects. Systolic shear rate and radius were measured from the velocity profile via a best-fit parabola. Systolic shear rate decreased immediately after cuff inflation (404 ± 78 to 233 ± 75 sec ^-1 p < .0001). Radius decreased at 2 min into inflation (3.52 ± .41 to 3.43 ± .42 mm, p < .0001). In conclusion, arterial constriction during reduced flow can be measured using PCMRI. This new method may add important information toward a comprehensive evaluation of endothelial function.

Original language	English (US)
Pages (from-to)	615-621
Number of pages	7
Journal	Journal of Cardiovascular Magnetic Resonance
Volume	7
Issue number	4
DOIs	https://doi.org/10.1081/JCMR-200065578
State	Published - 2005

Keywords

Blood flow
Endothelial function
Magnetic resonance imaging
Vasoconstriction

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Family Practice
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1081/JCMR-200065578

Cite this

@article{860ed0b66c8e42c89e477b4cbb2e2700,

title = "A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging: Vasoconstriction during reduced shear",

abstract = "We investigated whether endothelial-dependent arterial constriction during reduced shear can be measured using phase contrast magnetic resonance imaging (PCMRI). A cross-section of the femoral artery was acquired during a 5-minute distal occlusion in 33 subjects. Systolic shear rate and radius were measured from the velocity profile via a best-fit parabola. Systolic shear rate decreased immediately after cuff inflation (404 ± 78 to 233 ± 75 sec -1 p < .0001). Radius decreased at 2 min into inflation (3.52 ± .41 to 3.43 ± .42 mm, p < .0001). In conclusion, arterial constriction during reduced flow can be measured using PCMRI. This new method may add important information toward a comprehensive evaluation of endothelial function.",

keywords = "Blood flow, Endothelial function, Magnetic resonance imaging, Vasoconstriction",

author = "Silber, {Harrya A.} and Pamela Ouyang and Bluemke, {David A.} and Gupta, {Sandeep N.} and Foo, {Thomas K.} and Lima, {Joao A.C.}",

year = "2005",

doi = "10.1081/JCMR-200065578",

language = "English (US)",

volume = "7",

pages = "615--621",

journal = "Journal of Cardiovascular Magnetic Resonance",

issn = "1097-6647",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging

T2 - Vasoconstriction during reduced shear

AU - Silber, Harrya A.

AU - Ouyang, Pamela

AU - Bluemke, David A.

AU - Gupta, Sandeep N.

AU - Foo, Thomas K.

AU - Lima, Joao A.C.

PY - 2005

Y1 - 2005

N2 - We investigated whether endothelial-dependent arterial constriction during reduced shear can be measured using phase contrast magnetic resonance imaging (PCMRI). A cross-section of the femoral artery was acquired during a 5-minute distal occlusion in 33 subjects. Systolic shear rate and radius were measured from the velocity profile via a best-fit parabola. Systolic shear rate decreased immediately after cuff inflation (404 ± 78 to 233 ± 75 sec -1 p < .0001). Radius decreased at 2 min into inflation (3.52 ± .41 to 3.43 ± .42 mm, p < .0001). In conclusion, arterial constriction during reduced flow can be measured using PCMRI. This new method may add important information toward a comprehensive evaluation of endothelial function.

AB - We investigated whether endothelial-dependent arterial constriction during reduced shear can be measured using phase contrast magnetic resonance imaging (PCMRI). A cross-section of the femoral artery was acquired during a 5-minute distal occlusion in 33 subjects. Systolic shear rate and radius were measured from the velocity profile via a best-fit parabola. Systolic shear rate decreased immediately after cuff inflation (404 ± 78 to 233 ± 75 sec -1 p < .0001). Radius decreased at 2 min into inflation (3.52 ± .41 to 3.43 ± .42 mm, p < .0001). In conclusion, arterial constriction during reduced flow can be measured using PCMRI. This new method may add important information toward a comprehensive evaluation of endothelial function.

KW - Blood flow

KW - Endothelial function

KW - Magnetic resonance imaging

KW - Vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=23844505210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23844505210&partnerID=8YFLogxK

U2 - 10.1081/JCMR-200065578

DO - 10.1081/JCMR-200065578

M3 - Article

C2 - 16136850

AN - SCOPUS:23844505210

SN - 1097-6647

VL - 7

SP - 615

EP - 621

JO - Journal of Cardiovascular Magnetic Resonance

JF - Journal of Cardiovascular Magnetic Resonance

IS - 4

ER -

A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging: Vasoconstriction during reduced shear

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this