A novel classification of lung cancer into molecular subtypes

Lisandra West, Smruti J. Vidwans, Nicholas P. Campbell, Jeff Shrager, George R. Simon, Raphael Bueno, Phillip A. Dennis, Gregory A. Otterson, Ravi Salgia

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


The remarkably heterogeneous nature of lung cancer has become more apparent over the last decade. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. The discovery of multiple molecular mechanisms underlying the development, progression, and prognosis of lung cancer, however, has created new opportunities for targeted therapy and improved outcome. In this paper, we define "molecular subtypes" of lung cancer based on specific actionable genetic aberrations. Each subtype is associated with molecular tests that define the subtype and drugs that may potentially treat it. We hope this paper will be a useful guide to clinicians and researchers alike by assisting in therapy decision making and acting as a platform for further study. In this new era of cancer treatment, the 'one-size-fits-all' paradigm is being forcibly pushed aside-allowing for more effective, personalized oncologic care to emerge.

Original languageEnglish (US)
Article numbere31906
JournalPloS one
Issue number2
StatePublished - Feb 21 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General


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