A new version of the thalamic disinhibition hypothesis of central pain

A. D. Craig; D. Bowsher; R. R. Tasker; F. A. Lenz; P. M. Dougherty; Z. Wiesenfeld- Hallin

A new version of the thalamic disinhibition hypothesis of central pain

A. D. Craig, D. Bowsher, R. R. Tasker, F. A. Lenz, P. M. Dougherty, Z. Wiesenfeld- Hallin

Research output: Contribution to journal › Review article › peer-review

Abstract

The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.

Original language	English (US)
Pages (from-to)	1-28
Number of pages	28
Journal	Pain Forum
Volume	7
Issue number	1
State	Published - 1998
Externally published	Yes

Keywords

Cingulate
Insula
Pain
Thalamus
Thermoreception

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology
Anesthesiology and Pain Medicine

Cite this

@article{a01c8c2d110d4aefac43b456252375df,

title = "A new version of the thalamic disinhibition hypothesis of central pain",

abstract = "The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.",

keywords = "Cingulate, Insula, Pain, Thalamus, Thermoreception",

author = "Craig, {A. D.} and D. Bowsher and Tasker, {R. R.} and Lenz, {F. A.} and Dougherty, {P. M.} and {Wiesenfeld- Hallin}, Z.",

note = "Funding Information: From the Divisions of Neurobiology and Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona. Supported by National Institutes of Health Grant NS-25616 and the Atkinson Pain Research Fund administered by the Barrow Neurological Foundation. Reprint requests: A. D. Craig, Division of Neurobiology, BNI, 350 West Thomas Road, Phoenix, AZ 85013. {\textcopyright} 1998 the American Pain Society 1058-9139/0701-0001 $5.00/0 Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.",

year = "1998",

language = "English (US)",

volume = "7",

pages = "1--28",

journal = "Journal of Pain",

issn = "1526-5900",

publisher = "Churchill Livingstone",

number = "1",

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T1 - A new version of the thalamic disinhibition hypothesis of central pain

AU - Craig, A. D.

AU - Bowsher, D.

AU - Tasker, R. R.

AU - Lenz, F. A.

AU - Dougherty, P. M.

AU - Wiesenfeld- Hallin, Z.

N1 - Funding Information: From the Divisions of Neurobiology and Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona. Supported by National Institutes of Health Grant NS-25616 and the Atkinson Pain Research Fund administered by the Barrow Neurological Foundation. Reprint requests: A. D. Craig, Division of Neurobiology, BNI, 350 West Thomas Road, Phoenix, AZ 85013. © 1998 the American Pain Society 1058-9139/0701-0001 $5.00/0 Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.

PY - 1998

Y1 - 1998

N2 - The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.

AB - The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.

KW - Cingulate

KW - Insula

KW - Pain

KW - Thalamus

KW - Thermoreception

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M3 - Review article

AN - SCOPUS:0031967098

SN - 1526-5900

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JO - Journal of Pain

JF - Journal of Pain

IS - 1

ER -

A new version of the thalamic disinhibition hypothesis of central pain

Abstract

Keywords

ASJC Scopus subject areas

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