A new syndrome of familial aplastic anemia and chronic liver disease

Muzaffar H. Qazilbash, Johnson M. Liu, Adrianna Vlachos, Stephen Fruchtman, Hans Messner, Alvin Zipursky, Blanche P. Alter, Neal S. Young

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This report describes a new familial syndrome characterized by a combination of bone marrow failure and chronic liver disease. This disorder appears to be genetic in origin with an autosomal dominant inheritance and was characterized by hyperactivity of the immune system with increased activated cytotoxic T lymphocytes in peripheral blood and bone marrow and the presence of γ-interferon messenger RNA in bone marrow of several cases.

Original languageEnglish (US)
Pages (from-to)164-167
Number of pages4
JournalActa Haematologica
Issue number3
StatePublished - Feb 1997
Externally publishedYes


  • γ-interferon
  • Activated cytotoxic T lymphocytes
  • Bone marrow failure
  • Chronic liver disease

ASJC Scopus subject areas

  • Hematology


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