A new PET fluorescent sensor for Zn2+

Jiangli Fan, Xiaojun Peng, Yunkou Wu, Erhu Lu, Jun Hou, Hongbing Zhang, Rong Zhang, Xinmei Fu

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


A new Zn2+ fluorescent sensor NIDPA, with 1,8-naphthalimide as reporting group and di-2-picolylamine (DPA) as recognizing group, has been synthesized via simple steps. Based on photo-induced electron transfer (PET) mechanism, NIDPA has a five-fold fluorescent enhancement and 10 nm absorption blue-shift under simulated physiological conditions corresponding to the binding of Zn2+. Apparent dissociation constant for Zn2+ (Kd) is 0.83 nM, and Ca2+, Mg2+, Fe 2+, Ni2+ and Cr3+have little influence on fluorescent enhancement. These results suggest that NIDPA can be used to quantitatively and selectively measure the concentration of Zn2+ around sub-nanomolar range.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalJournal of Luminescence
Issue number2
StatePublished - Aug 2005
Externally publishedYes


  • 1,8-naphthalimide
  • Fluorescent probe
  • Fluorescent sensors
  • PET
  • Zinc ion

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • General Chemistry
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics


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