A new member of the frizzled family from Drosophila functions as a wingless receptor

Purnima Bhanot; Marcel Brink; Cindy Harryman Samos; Jen Chih Hsieh; Yanshu Wang; Jennifer P. Macke; Deborah Andrew; Jeremy Nathans; Roel Nusse

doi:10.1038/382225a0

A new member of the frizzled family from Drosophila functions as a wingless receptor

Purnima Bhanot, Marcel Brink, Cindy Harryman Samos, Jen Chih Hsieh, Yanshu Wang, Jennifer P. Macke, Deborah Andrew, Jeremy Nathans, Roel Nusse

School of Medicine

Research output: Contribution to journal › Article › peer-review

1159 Scopus citations

Abstract

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.

Original language	English (US)
Pages (from-to)	225-231
Number of pages	7
Journal	Nature
Volume	382
Issue number	6588
DOIs	https://doi.org/10.1038/382225a0
State	Published - Jul 18 1996

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title = "A new member of the frizzled family from Drosophila functions as a wingless receptor",

abstract = "Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.",

author = "Purnima Bhanot and Marcel Brink and Samos, {Cindy Harryman} and Hsieh, {Jen Chih} and Yanshu Wang and Macke, {Jennifer P.} and Deborah Andrew and Jeremy Nathans and Roel Nusse",

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AU - Bhanot, Purnima

AU - Brink, Marcel

AU - Samos, Cindy Harryman

AU - Hsieh, Jen Chih

AU - Wang, Yanshu

AU - Macke, Jennifer P.

AU - Andrew, Deborah

AU - Nathans, Jeremy

AU - Nusse, Roel

PY - 1996/7/18

Y1 - 1996/7/18

N2 - Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.

AB - Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.

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A new member of the frizzled family from Drosophila functions as a wingless receptor

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