TY - JOUR
T1 - A new lipase in regulating lipid mobilization
T2 - Hormone-sensitive lipase is not alone
AU - Raben, Daniel M.
AU - Baldassare, Joseph J.
PY - 2005/3
Y1 - 2005/3
N2 - Three papers recently appeared simultaneously that identify a new triacylglycerol lipase. Zimmerman et al. identified this lipase as adipocyte triacylglycerol lipase (ATGL). Jenkins et al. identified it as the ζ-isoform of a calcium-independent phospholipase A2 (iPLA 2), whereas Villena et al. found this enzyme and called it desnutrin. Interestingly, if, as implied, this lipase works in concert with hormone-sensitive lipase, then our concept of regulated fatty acid mobilization from triacylglycerols will have to be revised.
AB - Three papers recently appeared simultaneously that identify a new triacylglycerol lipase. Zimmerman et al. identified this lipase as adipocyte triacylglycerol lipase (ATGL). Jenkins et al. identified it as the ζ-isoform of a calcium-independent phospholipase A2 (iPLA 2), whereas Villena et al. found this enzyme and called it desnutrin. Interestingly, if, as implied, this lipase works in concert with hormone-sensitive lipase, then our concept of regulated fatty acid mobilization from triacylglycerols will have to be revised.
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U2 - 10.1016/j.tem.2005.01.009
DO - 10.1016/j.tem.2005.01.009
M3 - Short survey
C2 - 15734142
AN - SCOPUS:13944255725
SN - 1043-2760
VL - 16
SP - 35
EP - 36
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 2
ER -