A new insight into pathophysiological mechanisms of zinc in Diarrhea

Kazi Mirajul Hoque, Rafiquel Sarker, Sandra E. Guggino, Chung Ming Tse

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Scopus citations


An increasing amount of data showing the beneficial use of zinc (Zn) in treating diarrhea continues to emerge from epidemiological and clinical trials. However, without a thorough understanding of physiological mechanisms of Zn, it does not support policy recommendation to advocate the therapeutic use of Zn. Our data demonstrate that Zn is a potential antidiarrheal agent that provides substantial benefit by stimulating sodium absorption and inhibiting chloride secretion in intestinal epithelial cells. Thus, inclusion of Zn in oral rehydration solution (ORS) has the potential to markedly augment the effectiveness of ORS in the treatment of diarrhea.

Original languageEnglish (US)
Title of host publicationMolecular Structure and Function of the Tight Junction From Basic Mechanisms to Clinical Manifestations
PublisherBlackwell Publishing Inc.
Number of pages6
ISBN (Print)9781573317498
StatePublished - May 2009

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Cl secretion
  • Diarrhea
  • Na absorption
  • T84
  • Zinc

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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