A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays

Phyllis C. Leppert; William H. Catherino; James H. Segars

doi:10.1016/j.ajog.2005.12.059

A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays

Phyllis C. Leppert, William H. Catherino, James H. Segars

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

Original language	English (US)
Pages (from-to)	415-420
Number of pages	6
Journal	American journal of obstetrics and gynecology
Volume	195
Issue number	2
DOIs	https://doi.org/10.1016/j.ajog.2005.12.059
State	Published - Aug 2006
Externally published	Yes

Keywords

Collagen
Extracellular matrix
Fibroids
Keloid
Leiomyoma
Microarray

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2005.12.059

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title = "A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays",

abstract = "This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.",

keywords = "Collagen, Extracellular matrix, Fibroids, Keloid, Leiomyoma, Microarray",

author = "Leppert, {Phyllis C.} and Catherino, {William H.} and Segars, {James H.}",

note = "Funding Information: Supported, in part, by the Intramural Research Program of the Reproductive Biology and Medicine Branch, NICHD, NIH. ",

year = "2006",

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AU - Leppert, Phyllis C.

AU - Catherino, William H.

AU - Segars, James H.

N1 - Funding Information: Supported, in part, by the Intramural Research Program of the Reproductive Biology and Medicine Branch, NICHD, NIH.

PY - 2006/8

Y1 - 2006/8

N2 - This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

AB - This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

KW - Collagen

KW - Extracellular matrix

KW - Fibroids

KW - Keloid

KW - Leiomyoma

KW - Microarray

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JF - American journal of obstetrics and gynecology

IS - 2

ER -

A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays

Abstract

Keywords

ASJC Scopus subject areas

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