A new class of steroids inhibits angiogenesis in the presence of hepanin or a heparin fragment

Rosa Crum; Sandor Szabo; Judah Folkman

doi:10.1126/science.2416056

A new class of steroids inhibits angiogenesis in the presence of hepanin or a heparin fragment

Rosa Crum, Sandor Szabo, Judah Folkman

Research output: Contribution to journal › Article › peer-review

455 Scopus citations

Abstract

Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations ofthe pregnane nucleus. These compounds are here named angiostatic steroids.

Original language	English (US)
Pages (from-to)	1375-1378
Number of pages	4
Journal	Science
Volume	230
Issue number	4732
DOIs	https://doi.org/10.1126/science.2416056
State	Published - 1985
Externally published	Yes

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title = "A new class of steroids inhibits angiogenesis in the presence of hepanin or a heparin fragment",

abstract = "Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations ofthe pregnane nucleus. These compounds are here named angiostatic steroids.",

author = "Rosa Crum and Sandor Szabo and Judah Folkman",

year = "1985",

doi = "10.1126/science.2416056",

language = "English (US)",

volume = "230",

pages = "1375--1378",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - A new class of steroids inhibits angiogenesis in the presence of hepanin or a heparin fragment

AU - Crum, Rosa

AU - Szabo, Sandor

AU - Folkman, Judah

PY - 1985

Y1 - 1985

N2 - Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations ofthe pregnane nucleus. These compounds are here named angiostatic steroids.

AB - Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations ofthe pregnane nucleus. These compounds are here named angiostatic steroids.

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U2 - 10.1126/science.2416056

DO - 10.1126/science.2416056

M3 - Article

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AN - SCOPUS:0022366074

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EP - 1378

JO - Science

JF - Science

IS - 4732

ER -

A new class of steroids inhibits angiogenesis in the presence of hepanin or a heparin fragment

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